Up 21 points he has A. Peterson I have Manningham can I hold the lead Monday night standard scoring?

Can you - yes. Rather you will or not remains to be seen. You only need to look at recent Monday games to know that just about anything can happen - or even yesterday's games. Did you see 170+ rushing yards out of Torain? Peterson's averaging 18.3 points per game but the Giants are the #9 defense against fantasy RBs. Both Smith and Nicks could be back which would considerably cut down on Manningham's prospects.